论文部分内容阅读
目的了解碘充足地区孕妇碘营养状况及新生儿甲状腺功能。方法选择天津市中心妇产科医院的174名妊娠晚期孕妇为调查对象,收集其空腹晨尿及新生儿脐带血,分别测定尿碘浓度及血清中游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、敏感促甲状腺激素(sTSH)水平。结果 174名孕妇尿碘中位数为217.06μg/L9,.2%孕妇碘过量2,7.6%碘缺乏;新生儿FT3、FT4s、TSH水平为(2.31±0.28)(、16.50±1.34)pmol/L、4.71(3.96～6.04)μU/mL;整体孕妇尿碘水平与新生儿FT3、FT4s、TSH水平无相关性(P>0.05),不同碘营养状况孕妇所产新生儿FT3、FT4水平在各组间差异无统计学意义(P<0.05),碘不足组孕妇所产新生儿的sTSH水平高于碘超足量组;男婴的sTSH水平高于女婴,且男婴的sTSH更偏向于高值分布,经阴道产的新生儿sTSH水平高于剖宫产。结论碘充足地区孕妇整体碘水平适宜,但仍存在碘缺乏和碘过量个体,碘缺乏孕妇所产新生儿患甲减、亚甲减的风险较高;性别和生产方式影响新生儿的sTSH水平。
Objective To understand the nutritional status of iodine in pregnant women with adequate iodine and neonatal thyroid function. Methods One hundred and seventy-four pregnant women of the third trimester of pregnancy in Central Hospital of Obstetrics and Gynecology of Tianjin were enrolled in this study. Urine iodine concentration and free triiodothyronine (FT3) were measured in urine of fresh morning urine and neonatal umbilical cord blood. Free thyroxine (FT4), sensitive to thyroid stimulating hormone (sTSH) levels. Results The median of urinary iodine in 174 pregnant women was 217.06μg / L9, the excess of iodine in 2% pregnant women was 2,7.6%, the level of FT3, FT4s and TSH in neonates was (2.31 ± 0.28) (16.50 ± 1.34) pmol / L, 4.71 (3.96 ~ 6.04) μU / mL. There was no correlation between the level of urinary iodine and FT3, FT4s and TSH levels in neonates (P> 0.05). The levels of FT3 and FT4 in neonates with different iodine nutrition status There was no significant difference between groups (P <0.05). The levels of sTSH in neonates born to iodine deficient group were higher than those in iodine plus enough group. The sTSH level in male infants was higher than that in female infants, and the sTSH in male infants was more in favor of High value distribution, vaginal neonatal sTSH levels higher than cesarean section. Conclusion The iodine level of pregnant women in adequate iodine area is suitable, but there are still iodine deficiency and iodine excess individuals. Neonates born to iodine deficiency pregnant women suffer from a high risk of hypothyroidism and hypothyroidism. Sex and mode of production affect the sTSH levels in neonates.