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5. Establishing guidelines for CAR-T cells： challenges and considerations

Establishing guidelines for CAR-T cells： challenges and considerations

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：accessw2009

【摘 要】

：

T cells, genetically modified by chimeric antigen receptors(CAR-T), are endowed with specificity to a desired antigen and are cytotoxic to cells expressing the

【作 者】

：

Wei Wang Di-Yuan Qin Bing-Lan 

【机 构】

：

StateKeyLaboratoryofBiotherapy/CollaborativeInnovationCenterforBiotherapy,DepartmentofEmergency

【出 处】

：

中国科学：生命科学英文版

【发表日期】

：

2016年4期

【关键词】

：

T细胞 指南 基因治疗 抗原特异性 恶性血液病 受体基因 细胞毒性 免疫疗法 chimeric antigen receptor CAR-T cells gui 

【基金项目】

：

supported by the National High Technology Research and Development Program of China （2014AA020704）, the National Natural and Scientific Foundation of China （81201789/H1611, 81572981/H1611, 81400057/H0

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T cells, genetically modified by chimeric antigen receptors(CAR-T), are endowed with specificity to a desired antigen and are cytotoxic to cells expressing the targeted antigen. CAR-T-based cancer immunotherapy is a promising therapy for curing hematologi

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