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目的:本文采用研磨法制备了对乙酰氨基酚-β-环糊精（β－ＣＤ）包合物，熔融法制备了其固体分散体。方法：建立了对酰氨基酚包合物及其固体分散体外溶出度测定方法。结果：对乙酰氨基酚包合物（１：１Ｗ／Ｗ）（Ａ）和ＰＥＧ６０００固体分散体（１：２Ｗ／Ｗ）（Ｂ）的体外溶出参数Ｋｒ、Ｔ(５０)、Ｔｄ分别（Ａ）：０．８３３ｍｉｎ（-１）、３．９ｍｉｎ和４．４ｍｉｎ；（Ｂ）：０．５０６ｍｉｎ（-１）、４．４ｍｉｎ和５．１ｍｉｎ。结论：经t检验，对乙酰氨基酚包合物及固体分散体与胶囊剂之间的Ｔ(５０)、Ｔｄ均有极显著性差异（Ｐ＜０．０１）。
OBJECTIVE: In this paper, acetaminophen-β-cyclodextrin (β-CD) inclusion complex was prepared by grinding method and its solid dispersion was prepared by melt method. Methods: A method for the determination of the dissolution of amidophenol inclusion complex and its solid dispersion was established. Results: Dissolution parameters Kr, T (50), Td (A) in vitro for acetaminophen inclusion complex (A) and PEG 6000 solid dispersion (1: 2 W / W) : 0.833 min (-1), 3.9 min and 4.4 min; (B): 0.506 min (-1), 4.4 min and 5.1 min. Conclusion: The T (50) and Td between acetaminophen inclusion complex, solid dispersion and capsule have significant difference (P <0.01) by t test.