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目的观查周期型马来丝虫在小白鼠体内发育和病理变化。方法每只鼠腹腔内注射从东乡伊蚊收集60—200条感染期幼虫，定期抽查微丝蚴并解剖观察病理变化。结果在感染后30—310天解剖分别检获Ⅳ期幼虫.童虫和成虫，成虫阳性率为34.62％（9／26），主要病变为淋巴管炎、淋巴结炎，及其周围炎，在肺、脾、睾丸和精索可见淋巴栓塞，合有成虫和炎细胞，肺部可见退行性变的成虫和幼虫，形成丝虫性肉芽肿性病变。结论结果证实马来丝虫经沙鼠再传至小白鼠体内可发育到成虫并产生微丝蚴，可用以抗丝虫药物筛选，免疫学和病理变化等研究。
Objective To investigate the development and pathological changes of Cyclophilus malayi in mice. Methods Each mouse was injected intraperitoneally with 60-200 infective larvae collected from Aedes albopictus. The microfilariae were randomly spotted and dissected to observe the pathological changes. Results The stage Ⅳ larvae were seized 30 days to 310 days after infection.The positive rate of adult and adult worms was 34.62% (9/26), and the main pathological changes were lymphangitis, lymphadenitis and peripheral inflammation, Spleen, testis and spermatic cord can be seen lymphatic embolism, together with adult and inflammatory cells, degenerative lung visible growth of adults and larvae, the formation of filarial granulomatous lesions. Conclusion The results showed that the male worm could be developed into adult and produce microfilariae via reassuring gerbils, which could be used to screen anti-filariasis drugs, immunology and pathological changes.