前列腺素 E1 ( PGE1 )是一种二十烷类的化合物 ,具有舒张血管 ,抑制中性粒细胞及血小板聚集、活化等作用。脂质体携载前列腺素 E1 ( L ipo-PGE1 )是 PGE1的一种相对稳定有效的剂型。通过阐述 PGE1在中性粒细胞的聚集、活化 ,氧自由基的产生 ,钙离子超载等影响缺血再灌注损伤的重要环节的作用 ,以及对血小板功能的抑制作用和对血管内皮因子的调节作用等 ,揭示其抗缺血再灌注损伤的作用机制。 Prostaglandin E1 (PGE1) is an eicosane compound that has the effects of relaxing blood vessels, inhibiting the aggregation and activation of neutrophils and platelets. Liposome-borne prostaglandin E1 (Lpo-PGE1) is a relatively stable and effective form of PGE1. Through the PGE1 in the neutrophil aggregation, activation, the generation of oxygen free radicals, calcium overload and other important aspects of the impact of ischemia-reperfusion injury, as well as the inhibition of platelet function and regulation of vascular endothelial factor Etc., to reveal its mechanism of anti-ischemia-reperfusion injury.