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运用DMN大鼠肝纤维化模型,通过H.E、胶原染色、免疫组化、电镜等病理形态学方法观察旋复花汤治疗大鼠肝纤维化和肝窦毛细血管化的作用。结果发现旋复花汤能有效阻断大鼠肝纤维化和肝窦毛细血管化的形成证明活血化瘀为主方药治疗肝纤维化的有效性,提示(1)肝纤维化过程中有“血瘀”之存在。(2)肝窦毛细血管化可能是肝纤维化“血瘀”证的一个重要环节。
The hepatic fibrosis model of DMN rats was used to observe the effects of Infuhuahua Decoction on hepatic fibrosis and hepatic sinusoidal capillarization by pathological morphology such as H.E, collagen staining, immunohistochemistry and electron microscopy. The results showed that Xuanfuhua Decoction can effectively block the formation of hepatic fibrosis and hepatic sinusoidal capillaries in rats and prove the effectiveness of the main method of promoting blood circulation and dissipating stasis in the treatment of hepatic fibrosis, suggesting that (1) there is “blood in the process of liver fibrosis” The existence of 瘀 。. (2) The sinusoidal hepatic vascularization may be an important part of the liver fibrosis “bloody” certificate.