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脑的能量90%由葡萄糖提供,当葡萄糖供应不足时,新生儿产生酮体或脂肪酸等中间代谢产物的能力有限,难以提供足够的能量代偿,故应对缺氧缺血性脑病的新生儿增加葡萄糖的供给以降低缺氧缺血陛脑损伤。然而,对缺氧缺血性脑损伤的成年动物模型和发生卒中的成年患者的研究表明,在窒息初期过度供给葡萄糖反而不利。缺氧后理想的血糖水平并不确切。本文讨论新生儿缺氧缺血性脑病患儿血糖变化与脑损伤的关系。一、动物研究结果
90% of brain energy is provided by glucose. When glucose supply is insufficient, newborn’s ability to produce intermediate metabolites such as ketones or fatty acids is limited and it is difficult to provide adequate energy compensation. Therefore, neonatal hypoxic-ischemic encephalopathy should be increased Glucose supply reduces hypoxic-ischemic brain damage. However, studies in adult animal models of hypoxic-ischemic brain damage and in adult patients with stroke have shown that it is disadvantageous to over-supply glucose early in the asphyxiation. The ideal blood glucose level after hypoxia is not exact. This article discusses the neonatal hypoxic-ischemic encephalopathy in children with changes in blood glucose and brain injury. First, the results of animal research