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目的:观察六月青皂苷(the saponins of Liuyueqing,TLYQ)抗鸭乙型肝炎病毒(duck hepatitis Bvirus,DHBV)与保护肝细胞的作用。方法:将DHBV-DNA阳性麻鸭随机分为TLYQ高、中、低剂量治疗组、拉米夫定组和模型组,分别给予相应药物进行干预。用药前、后7 d,14 d及停药后7 d,取静脉血,检测DH-BV-DNA拷贝量和ALT/AST变化情况。结果:TLYQ大剂量组给药后d 7,d 14即能明显抑制DHBV-DNA,停药后仍有一定的抑制作用。中、低剂量组与模型组比较,有一定的病毒抑制作用。在用药后d 14,停药后d 7,ALT/AST较模型组明显下降,有显著性差异。结论:TLYQ具有有效抑制DHBV-DNA和保护肝细胞的作用。
Objective: To observe the effect of the saponins of Liuyueqing (TLYQ) against duck hepatitis B virus (DHBV) and the protection of hepatocytes. Methods: DHBV-DNA positive ducks were randomly divided into high, middle and low dose TLYQ treatment group, lamivudine group and model group, and the corresponding drugs were given respectively for intervention. Blood samples were collected before and 7 days, 14 days and 7 days after drug withdrawal to detect the change of DH-BV-DNA copy number and ALT / AST. Results: The dosage of DHBV-DNA of TLYQ high-dose group could significantly inhibit DHBV-DNA after d 7 and d 14 administration, and there was still some inhibition after stopping administration. Medium and low dose group compared with the model group, there is a certain degree of virus inhibition. After d 14, d 7 after stopping, ALT / AST decreased significantly compared with the model group, there was a significant difference. Conclusion: TLYQ can effectively inhibit DHBV-DNA and protect liver cells.