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目的:分析中医药联合化疗预防胃癌术后复发的效果。方法:检索中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库(Wan Fang)、Pub Med、the Cochrane library数据库自文章摘录起到2015年10月1日前关于中医药联合化疗预防胃癌术后复发的相关文献;由两名研究员按照纳入标准、筛选文献、质量评价后,采用Cochrane提供Revmen5.2软件进行Meta分析。结果:纳入5个研究对象,在中医药联合化疗胃癌术后复发方面,6个月复发率[RR=0.25,97%CI=(0.06,1.12),P=0.07],观察组与对照组比较,差异无统计学意义(P>0.05)。12个月复发率[RR=0.48,97%CI=(0.29,0.80),P=0.005]、24个月复发率[RR=0.57,97%CI=(0.40,0.81),P=0.002]、36个月复发率[RR=0.53,97%CI=(0.35,0.81),P=0.003],观察组均低于对照组,差异有统计学意义(P<0.05)。结论:中医药联合化疗预防胃癌术后复发优于单纯西医治疗。
Objective: To analyze the effect of traditional Chinese medicine combined with chemotherapy in preventing postoperative recurrence of gastric cancer. Methods: The CNKI, VIP, Wan Fang, Pub Med, the Cochrane database were searched from the excerpt of the article until Oct. 1, 2015. About Chinese medicine combined Chemotherapy to prevent postoperative recurrence of gastric cancer related literature; by two researchers in accordance with inclusion criteria, screening literature, quality evaluation, using Cochrane Revmen5.2 software for meta-analysis. Results: Five subjects were enrolled in this study. The recurrence rate of 6-month follow-up after 6-month recurrence of gastric cancer with traditional Chinese medicine (RR = 0.25,97% CI = (0.06,1.12), P = 0.07] , The difference was not statistically significant (P> 0.05). The relapse rate at 12 months [RR = 0.48, 97% CI = (0.29, 0.80), P = 0.005], 24 months relapse rate [RR = 0.57,97% CI = (0.40,0.81), P = 0.002] 36 months recurrence rate (RR = 0.53,97% CI = (0.35,0.81), P = 0.003], the observation group were lower than the control group, the difference was statistically significant (P <0.05). Conclusion: The combination of Chinese medicine and chemotherapy in the prevention of postoperative recurrence of gastric cancer is better than that of western medicine alone.