为考查化学结构和抗惊活性之间的关系,设计并合成了一系列β位取代的桂皮酰胺化合物。发现其中有三个化合物(β位乙基、丙基、氨基取代物)抗惊活性较高。研究化学结构和抗惊活性的关系可看出:β位以给电子基团取代,并且苯环和羰基保持共轭体系的分子可增强抗惊活性。 In order to investigate the relationship between chemical structure and anti-shock activity, a series of beta-substituted cinnamide compounds were designed and synthesized. Three compounds (β-ethyl, propyl, amino substitution) were found to have higher anti-shock activity. Studying the relationship between chemical structure and anti-shock activity, it can be seen that the β-position is substituted with an electron-donating group, and molecules in which the benzene ring and the carbonyl group hold the conjugated system enhance anti-shock activity.