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目的探讨儿童淋巴瘤的临床和病理特点。方法收集1996年-2009年75例淋巴瘤患儿临床病理资料,进行光镜观察、免疫组织化学染色分析,对初步诊断为伯基特淋巴瘤和弥散大B细胞淋巴瘤的病例进行c-myc基因荧光原位杂交检测。根据WHO 2008年淋巴组织肿瘤分类标准进行分类。结果 75例儿童淋巴瘤中男57例,女18例,男女之比为3.171。发病平均年龄8.74岁。发病部位:淋巴结内32例(42.7%);淋巴结外43例(57.3%),以胃肠道(29.3%)为主。组织类型包括:霍奇金淋巴瘤13例(17.3%),淋巴母细胞淋巴瘤16例(21.3%),间变性大细胞淋巴瘤12例(16.0%),伯基特淋巴瘤和弥散大B细胞淋巴瘤33例(44.0%),小淋巴细胞性淋巴瘤1例(1.3%)。对初步诊断为伯基特淋巴瘤和弥散大B细胞淋巴瘤病例进行荧光原位杂交检测进行进一步诊断,结果显示,该组28例中存在c-myc基因改变者18例。结论儿童淋巴瘤以男性多见,发病部位以淋巴结和胃肠道多见。最常见的组织学类型依次为伯基特淋巴瘤、淋巴母细胞淋巴瘤、霍奇金淋巴瘤、间变性大细胞淋巴瘤和弥散大B细胞淋巴瘤。
Objective To investigate the clinical and pathological features of childhood lymphoma. Methods The clinical and pathological data of 75 cases of lymphoma from 1996 to 2009 were collected and observed by light microscopy and immunohistochemical staining. The cases of primary diagnosis of Burkitt’s lymphoma and diffuse large B-cell lymphoma were analyzed by c-myc Gene Fluorescence in Situ Hybridization Assay. According to the WHO 2008 Lymphatic Tumor Classification criteria. Results 75 cases of children with lymphoma 57 males and 18 females, male to female ratio was 3.17 1. The average incidence of 8.74 years of age. The incidence of sites: 32 cases (42.7%) in the lymph nodes; 43 cases (57.3%) of the lymph nodes to the gastrointestinal tract (29.3%). Tissue types included 13 Hodgkin’s lymphoma (17.3%), 16 lymphoblastic lymphoma (21.3%), 12 anaplastic large cell lymphoma (16.0%), Burkitt’s lymphoma and diffuse large B Thirty-three cases (44.0%) had lymphocytic cell lymphoma and one small lymphocytic lymphoma (1.3%). Further diagnosis of primary diagnosis of Burkitt’s lymphoma and diffuse large B cell lymphoma by fluorescence in situ hybridization showed that there were 18 cases of c-myc gene mutation in the group of 28 cases. Conclusion Children with lymphoma more common in men, the incidence of lymph nodes and gastrointestinal sites more common. The most common histological types were Burkitt’s lymphoma, lymphoblastic lymphoma, Hodgkin’s lymphoma, anaplastic large cell lymphoma and diffuse large B cell lymphoma.