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目的:分析台州市男男性行为者（MSM）中HIV阴性者和HIV感染者中新型毒品使用与肛管人乳头瘤病毒（HPV）感染的相关性。方法:采用横断面调查方法，分别于2016年8月至2017年10月在台州市4个区（县）CDC自愿咨询检测门诊采用方便抽样招募HIV阴性MSM、2016年8月至2019年6月招募台州市随访管理的HIV感染MSM。采用问卷调查收集研究对象社会人口学、性取向和性行为以及新型毒品使用等信息，采集研究对象肛管拭子样本进行HPV检测。采用n χn 2检验和logistic回归模型分析HIV感染和新型毒品使用与肛管HPV感染的相关性。n 结果:在MSM中，共69例HIV阴性者和345例HIV感染者。HIV阴性者的肛管HPV感染率（27.5%，19/69）低于HIV感染者（66.4%，229/345）（n χ2=36.114，n P<0.001）。HIV阴性者新型毒品使用率（17.4%，12/69）高于HIV感染者（7.0%，24/345）（n χ2=7.886，n P=0.005）。在HIV阴性者中，新型毒品使用率与发生同性群交性行为呈正相关（n P=0.036）；新型毒品使用者和未使用者的肛管HPV感染率分别为50.0%（6/12）和22.8%（13/57）（n χ2=3.674，n P=0.055）；在HIV感染者中，新型毒品使用者和未使用者的肛管HPV感染率分别为70.8%（17/24）和66.0%（212/321）（n χ2=0.230，n P=0.632）。多因素logistic回归分析结果显示，MSM的HIV感染是肛管HPV感染的正相关因素（n OR=5.42，95%n CI：2.92~10.06），新型毒品使用与肛管HPV感染无相关性（n OR=1.66，95%n CI：0.75~3.71）。n 结论:台州市MSM的HIV感染与肛管HPV感染呈正相关。新型毒品使用与高危性行为呈正相关，而与HPV感染关联有待进一步研究。“,”Objective:To explore the correlation between club drug use and anal canal human papillomavirus (HPV) infection in HIV-negative and HIV-positive men who have sex with men (MSM) in Taizhou.Methods:A cross-sectional survey was conducted in Taizhou. HIV-negative MSM were recruited by convenient sampling in voluntary counseling and testing clinics of Taizhou prefectural CDC from August 2016 to October 2017, and HIV-positive MSM were recruited through the routine follow-up and management by Taizhou prefectural CDC from August 2016 to June 2019. A face-to-face questionnaire interview was conducted to collect the information about the socio-demographic characteristics, sexual orientation, sexual behavior, club drug use and other information of the participants. Anal canal swabs were collected for HPV genotyping. The correlation between club drug use and the prevalence of HPV infection were evaluated with n χ2 test and logistic regression analysis.n Results:A total of 69 HIV-negative and 345 HIV-infected MSM were included. The prevalence of any type of anal canal HPV infection in HIV-negative MSM (27.5%, 19/69) was lower than that in HIV-positive MSM (66.4%, 229/345) (n χ2=36.114,n P<0.001). The prevalence of self-reported club drug use in HIV-negative MSM was higher (17.4%, 12/69) than that in HIV-positive MSM (7.0%, 24/345) (n χ2=7.886, n P=0.005). For HIV-negative MSM, the prevalence of club drug use was higher in MSM who had homosexual group sex (n P=0.036); the prevalence of HPV infection was 50.0% (6/12) in club drug users and 22.8% (13/57) in non-club drug users (n χ2=3.674, n P=0.055). For HIV-positive MSM, the prevalence of HPV infection was 70.8% (17/24) in club drug users and 66.0% (212/321) in non-club drug users (n χ2=0.230, n P=0.632). Multivariable logistic regression model showed that HPV infection in MSM was positively correlated with HIV infection (n OR=5.42, 95%n CI: 2.92-10.06), and the association between HPV infection and club drug use (n OR=1.66, 95%n CI: 0.75-3.71) was not significant.n Conclusions:HIV infection was positively correlated with anal canal HPV infection in MSM in Taizhou. Club drug use was positively correlated with high-risk sexual behaviors, while its association with HPV infection needs further study.