论文部分内容阅读
目的 :探讨单疱病毒性角膜炎伴发青光眼的临床特点、发病机理与治疗方法。方法 :对 2 1例患者的临床资料及实验室检查结果进行分析。结果 :2 1例患者中 ,盘状角膜基质炎 15例 ;角膜色素膜炎 4例 ;拟青光眼睫状体炎 2例。共同的临床表现特点是 :在原角膜病变的基础上出现眼胀痛 ,结膜充血加重 ,角膜上皮弥漫性水肿及不同程度的色素膜眼体征 ,眼压升高多在 6 .6 5 k Pa以上。 PCR检测外周血单疱病毒 型 DNA阳性 4例 (19.0 5 % )。 2 1例患者经过抗病毒及抗炎治疗均获临床治愈。结论 :本组病例多系单疱病毒通过内生性感染导致小梁炎与色素膜炎引起眼压升高 ,通过积极的抗病毒与抗炎治疗能迅速控制炎症与眼压。
Objective: To investigate the clinical features, pathogenesis and treatment of herpes simplex keratitis associated with glaucoma. Methods: The clinical data of 21 patients and the results of laboratory tests were analyzed. Results: Of the 21 patients, 15 had discoid corneal stroma, 4 had corneal meningitis, and 2 had pseudoclasis of ciliary body. Common clinical manifestations are: the original corneal lesions on the basis of eye pain, increased conjunctival hyperemia, diffuse edema of the corneal epithelium and varying degrees of pigmented eye signs, intraocular pressure increased more than 6.65 kPa. PCR detection of peripheral blood mononuclear virus DNA positive in 4 cases (19.0 5%). Twenty-one patients were clinically cured after antiviral and anti-inflammatory treatments. CONCLUSIONS: In this group of patients, multiple mycosis herpes simplex virus leads to increased intraocular pressure (ITI) caused by endogenous infections through trabecular inflammation and uveitis, and inflammation and intraocular pressure can be rapidly controlled through active antiviral and anti-inflammatory therapies.