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目的了解静态行为与心脑血管病死亡的关系。方法于2010年10月—2014年12月应用巢式病例对照研究方法对江苏省8 275名≥18周岁未患心脑血管病的常住居民作为研究队列进行随访,以队列中96例新发心脑血管病死亡患者作为病例组,并按照成组设计、病例与对照1:5的原则从随访队列中未发生心脑血管病事件人群中抽取480人作为对照组,应用多因素logistic回归分析方法,在调整可能的混杂因素后分析静态行为与心脑血管病死亡间的关系。结果在调整年龄、文化程度、家庭平均年收入、吸烟、饮酒和血压等因素后,每日静态行为时间≥6 h者心脑血管病死亡风险为每日静态行为时间<2 h者的5.94倍(95%CI=2.01~17.60);静态行为与吸烟行为在心脑血管病死亡上存在交互作用(OR_(交互)=1.37,95%CI=1.01~3.56),现在吸烟同时每日静态行为时间≥6 h者心脑血管病死亡风险为从不吸烟且每日静态行为时间<2 h者的2.46倍(95%CI=1.03~5.88),未发现静态行为与饮酒行为在心脑血管病死亡上存在交互作用(OR_(交互)=0.91,95%CI=0.78~1.06)。结论每日静态行为时间过长可以单独或通过与吸烟行为相互作用而增加心脑血管病的死亡风险。
Objective To understand the relationship between the static behavior and the death of cardiovascular and cerebrovascular diseases. Methods From October 2010 to December 2014, a nested case-control study was conducted to investigate the prevalence rate of 8 275 resident residents ≥18 years of age without cardiovascular and cerebrovascular diseases in Jiangsu Province as the research cohort. According to the principles of group design, case and control 1: 5, 480 patients who died of cerebrovascular disease were selected as the control group from the follow-up cohort without cardiovascular and cerebrovascular disease. Multivariate logistic regression analysis , After adjusting for possible confounding factors to analyze the relationship between the static behavior and the death of cardiovascular and cerebrovascular diseases. Results After adjusting for age, education level, average family income, smoking, drinking and blood pressure, the risk of death from cardiovascular and cerebrovascular diseases was 5.94 times of daily static behavioral time <2 h (95% CI = 2.01-17.60). There was interaction between static behavior and smoking behavior in the death of cardiovascular and cerebrovascular diseases (OR_ (interaction) = 1.37, 95% CI = 1.01 ~ 3.56). Now smoking and daily static behavior time The risk of cardiovascular and cerebrovascular diseases ≥6 h was 2.46 times (95% CI = 1.03-5.88) in patients who never smoked and had daily static behavioral time <2 h, and no statutory behavior and drinking behavior were found in cardiovascular and cerebrovascular diseases There was an interaction (OR_ (interaction) = 0.91, 95% CI = 0.78 ~ 1.06). Conclusions Daily static behavior for an extended period of time can increase the risk of death from cardiovascular disease, either alone or through interaction with smoking behavior.