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目的探讨小剂量递增补铁法治疗小儿中重度缺铁性贫血的疗效。方法 86例中重度缺铁性贫血婴幼儿随机分为对照组和治疗组,两组患儿给予不同剂量铁剂口服,分别于用药前及用药结束时检测血红蛋白(Hb)、红细胞计数(RBC)、红细胞比容(Hct)、平均红细胞容积(MCV)、平均红细胞血红蛋白量(MCH)、平均红细胞血红蛋白浓度(MCHC)、血清铁蛋白(SF)、总铁蛋白结合力(TIBC),并记录患儿服药期间的不良反应。结果铁剂治疗后,两组Hct、Hb、MCV、MCH、MCHC及SF较治疗前均升高,TIBC较前降低(P<0.05);两组总有效率差异无统计学意义(P>0.05)。治疗组不良反应发生率13.95%,对照组79.1%,差异有统计学意义(P<0.01)。结论小剂量递增补铁法治疗婴幼儿中-重度缺铁性贫血优于每日常规补铁疗法。
Objective To investigate the effect of small dose increasing iron supplementation on children with moderate to severe iron deficiency anemia. Methods Totally 86 infants with moderate and severe iron deficiency anemia were randomly divided into control group and treatment group. The two groups were given oral administration of iron at different doses. Hb, RBC, , Hct, MCV, MCH, MCHC, SF and TIBC were measured and recorded Adverse reactions during child medication. Results After treatment with iron, the levels of Hct, Hb, MCV, MCH, MCHC and SF in both groups were higher than those before treatment, and TIBC was lower than before (P <0.05). There was no significant difference in total effective rate between the two groups ). The incidence of adverse reactions in the treatment group was 13.95% and in the control group was 79.1%, the difference was statistically significant (P <0.01). Conclusion The small dose of increasing iron supplementation in the treatment of infantile moderate-severe iron deficiency anemia is better than the routine routine iron therapy.