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目的:研究香砂六君子汤加减对晚期胃癌患者应用替吉奥胶囊化疗后的减毒作用。方法:将符合纳入标准的48例晚期胃癌患者随机分为两组,各24例,两组均口服替吉奥胶囊化疗,治疗组在对照组基础上,于化疗前1天开始服用香砂六君子汤加减。两组均治疗42d后统计疗效。结果:中医证候改善率治疗组为87.5%,对照组为37.5%,两组比较差异有统计学意义(P<0.05);两组KPS评分改善率治疗组为87.5%,高于对照组的58.3%,差异有统计学意义(P<0.05);在不良反应发生情况方面,治疗组食欲减退、恶心呕吐、腹泻发生率较对照组低,差异有统计学意义(P<0.05),而骨髓抑制、肝功能损害的发生率相当,差异无统计学意义(P>0.05)。结论:对晚期胃癌患者,香砂六君子汤加减联合应用替吉奥化疗较替吉奥单药化疗在提高患者短期生活质量、减轻化疗毒副反应方面具有优势。
AIM: To study the attenuated effect of Xiangsha Liujunzi Decoction on patients with advanced gastric cancer after application of Tegi capsule. Methods: Forty-eight patients with advanced gastric cancer, who met the inclusion criteria, were randomly divided into two groups of 24 patients. Each group was treated with tegaserod orally. In the treatment group, on the basis of the control group, Gentleman soup addition and subtraction. Two groups were treated 42d after the statistical effect. Results: The improvement rate of TCM syndrome was 87.5% in the treatment group and 37.5% in the control group, with significant difference between the two groups (P <0.05). The improvement rate of KPS score was 87.5% in the two groups, higher than that in the control group 58.3%, the difference was statistically significant (P <0.05); in the incidence of adverse reactions, the treatment group, loss of appetite, nausea and vomiting, diarrhea incidence was lower than the control group, the difference was statistically significant (P <0.05) Inhibition, the incidence of liver damage is quite significant, the difference was not statistically significant (P> 0.05). Conclusion: In patients with advanced gastric cancer, Xiangsha Liujunzi Decoction combined with TEGO can improve the short-term quality of life and reduce the toxic side effects of chemotherapy.