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目的:探讨维A酸联合亚砷酸治疗急性早幼粒细胞白血病(APL)的效果。方法:抽取郑州颐和医院2018年12月至2019年12月收治的APL患者82例，采用随机数字表法分为参照组与研究组，参照组41例给予维A酸诱导化疗，研究组41例给予维A酸联合亚砷酸诱导化疗。比较两组临床治疗完全缓解率，诱导缓解时间，白细胞水平峰值，高白细胞血症维持时间，不良反应发生率，治疗3、6个月复发率及再次治疗完全缓解率。结果:研究组临床治疗完全缓解率高于参照组，差异有统计学意义(n P0.05)；研究组治疗6个月复发率低于参照组，差异有统计学意义(n P0.05)。n 结论:急性早幼粒细胞白血病临床治疗中，以维A酸联合亚砷酸诱导化疗，有利于缩短诱导缓解时间，提高完全缓解率，但存在一定药物不良反应。“,”Objective:To study the effect of tretinoin combined with arsenious acid on acute promyelocytic leukemia (APL).Methods:A total of 82 patients with APL in Zhengzhou Yihe Hospital from December 2018 to December 2019 were selected and divided into reference group and study group by random number table. Forty-one cases in the reference group were given tretinoin Induction chemotherapy, and 41 cases in the study group were given tretinoin combined with arsenous acid induction chemotherapy, and the clinical treatment complete remission rate, remission induction time, peak white blood cell level, maintenance time of hyperleukocytosis, incidence of adverse reactions, recurrence rate after 3, 6 months of treatment and complete remission rate after retreatment between the two groups were compared.Results:The clinical treatment complete remission rate of the study group was higher than that of the reference group (n P0.05); the recurrence rate of the study group after 6 months of treatment was lower than that of the reference group, the difference was statistically significant (n P0.05).n Conclusions:In the clinical treatment of acute promyelocytic leukemia, the use of tretinoin combined with arsenous acid to induce chemotherapy is beneficial to shorten the induction time and improve the complete remission rate, but there are certain drug side effects.