目的改进抗高血压药物阿折地平的合成工艺。方法以二苯甲胺和环氧氯丙烷为起始原料,经取代、酯化、酸化、缩合等反应制得抗高血压药物阿折地平。结果与结论目标化合物的结构经1H-NMR谱和质谱确证。总收率为30.88%,比文献收率提高了10.62%。改进后的方法操作简便,有利于工业化生产。 Objective To improve the synthetic process of anti-hypertensive drug azurite. Methods Benzophenamine and epichlorohydrin as starting materials, by substitution, esterification, acidification, condensation and other reactions obtained antihypertensive drug Azadirandine. Results and Conclusions The structures of the target compounds were confirmed by 1H-NMR and mass spectra. The total yield was 30.88%, which was 10.62% higher than the literature yield. The improved method is easy to operate and is conducive to industrial production.