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目的观察辛伐他汀与普罗布考对急性冠状动脉(冠脉)综合征可溶性细胞间粘附因子(SICM-1)的影响。方法 70例急性冠脉综合征患者,随机分成普罗布考组和辛伐他汀组,各35例。普罗布考组在基础治疗基础上给予普罗布考治疗,辛伐他汀组在基础治疗基础上给予辛伐他汀治疗,连服8周。比较服药前后测SICM-1水平。结果两组治疗后SICAM-1水平,明显低于治疗前(P<0.05)。结论普罗布考、辛伐他汀不仅可降低胆固醇水平,同时可降低血清SICAM-1水平,对血管内皮细胞有保护作用,可在临床广泛使用。
Objective To observe the effects of simvastatin and probucol on the expression of soluble intercellular adhesion molecule-1 (SICM-1) in patients with acute coronary syndrome (coronary syndrome). Methods Seventy patients with acute coronary syndrome were randomly divided into probucol group and simvastatin group, 35 in each. Probucol group was given probucol on the basis of basic treatment, and simvastatin group was given simvastatin on the basis of basic treatment for 8 weeks. Before and after taking the test SICM-1 levels. Results The SICAM-1 levels in both groups were significantly lower than those before treatment (P <0.05). Conclusions Probucol and simvastatin can not only lower the level of cholesterol, but also decrease the level of SICAM-1 in serum, which may have a protective effect on vascular endothelial cells and be widely used clinically.