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102例老年动脉粥样硬化患者(包括冠状动脉粥样硬化55例和主动脉粥样硬化47例)经随机分组、尼群地平及安慰剂双盲对照治疗4年,与安慰剂组相比,治疗组心血管并发症明显减少(P<0.05),血脂LDL—ch、Tch/HDL—ch、LDL—ch/HDL—ch及脂质过氧化物明显降低,提示尼群地平通过改变脂蛋白组分及比值、减轻动脉壁脂质过氧化损伤进而使动脉粥样硬化进展延缓或有所消退,可能是钙拮抗剂的抗动脉粥样硬化作用机制之一。
A total of 102 elderly patients with atherosclerosis (including 55 cases of coronary atherosclerosis and 47 cases of aortic atherosclerosis) were randomly assigned to receive either nitrendipine or placebo for 4 years. Compared with placebo, The cardiovascular complications in the treatment group were significantly reduced (P <0.05), and the levels of LDL-ch, Tch / HDL-ch, LDL-ch / HDL-ch and lipid peroxides were significantly decreased in the treatment group, Points and ratio, reduce arterial lipid peroxidation damage and thus make the progress of atherosclerosis retarded or subsided, may be one of the anti-atherosclerosis mechanism of calcium antagonists.