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环孢素(cyclosporine A,CsA)是一种高效免疫抑制药,临床广泛用于器官移植。由于CsA的药物动力学个体差异大,其血药浓度与疗效及毒性密切相关,故监测全血中CsA的血药浓度已成为临床使用CsA的常规医疗项目。现就几种常用检测方法综述如下。
Cyclosporine A (CsA) is a highly effective immunosuppressive drug widely used in organ transplantation. Due to the large individual differences in pharmacokinetics of CsA, the plasma concentration of CsA is closely related to its efficacy and toxicity. Therefore, the monitoring of CsA concentration in whole blood has become a routine medical project for the clinical use of CsA. Several commonly used detection methods are summarized below.