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意大利内科医生7月14日撰文指出,大剂量阿司匹林可以增加使用ACEI治疗充血性心力衰竭病人的病死率。 Dr.Maurizio D.Guazzi及其同事评估了344例患充血性心力衰竭且使用ACEI治疗的出院病人结果。研究对象为70岁或更小,且无文字记载的对ACEI或阿司匹林的禁忌症。其中235例只应用ACEI;45例每日合用160mg或更少的阿司匹林;64例每日合用325mg或更多的阿司匹林。 在最长达10年(平均为37.6个月)的随访后,有134例死亡。ACEI单用组的病死率为36％,低剂量阿司匹林合用组为33％,而高剂量合用组则为
Italian physician July 14 article pointed out that high-dose aspirin can increase the use of ACEI in patients with congestive heart failure mortality. Dr.Maurizio D. Guazzi and colleagues evaluated the results of 344 discharged patients treated with ACEI with congestive heart failure. Subjects were 70 or younger and had no documented contraindications to ACEI or aspirin. Of these, 235 received ACEI alone; 45 received aspirin 160 mg or less daily; and 64 received aspirin 325 mg or more daily. After up to 10 years (an average of 37.6 months) follow-up, 134 deaths occurred. The mortality rate of ACEI alone group was 36%, that of low-dose aspirin group was 33%, and that of high-dose combination group was