一氧化氮(NO)是一氧化氮合成酶(NOS)作用于底物左旋精氨酸(L—ARG)所合成,化学性质极不稳定。在体内它主要产生于血管内皮细胞、血管平滑肌细胞、枯否氏细胞及巨噬细胞。NOS可分为结构型(cNOS)和诱导型(iNOS)两类。左旋精氨酸甲酯(1—NAME)、N—甲基左旋精氨酸(L—NMMA)及N—硝基左旋精氨酸(L Nitric oxide (NO) is a nitric oxide synthase (NOS) acting on the substrate L-arginine (L-ARG) synthesis, very unstable chemical properties. It is mainly produced in the body of vascular endothelial cells, vascular smooth muscle cells, Kupffer cells and macrophages. NOS can be divided into two types: structural (cNOS) and inducible (iNOS). L-arginine methyl ester (1-NAME), N-methyl L-arginine (L-NMMA) and N-nitro L-arginine