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[目的]探讨鼻咽癌(NPC)患者放射治疗前后外周血清血管内皮细胞生长因子(VEGF)和碱性成纤维细胞生长因子(bFGF)的变化。[方法]42例NPC患者作为放疗组予以放射治疗,40例健康体检者作为正常对照组。采用酶联免疫吸附试验(ELISA)检测放疗前后NPC患者外周血清VEGF和bFGF的含量,并与对照组比较。[结果]放疗前NPC患者血清VEGF和bFGF显著升高,与对照组比较有统计学意义(P<0.01)。放疗后3个月NPC患者血清VEGF和bFGF明显下降,接近对照组水平(P>0.05),放疗后1年复发者血清VEGF和bFGF水平持续异常(P<0.01),未复发者血清VEGF和bFGF水平恢复正常(P>0.05)。放疗前后患者血清VEGF和bFGF的浓度变化呈正相关(P=0.0011,r=0.7981)。[结论]NPC患者血清中VEGF和bFGF高表达,测定NPC患者血清中VEGF和bFGF的变化对临床疗效观察和预后判断均有重要的临床意义。
[Objective] To investigate the changes of peripheral blood serum vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with nasopharyngeal carcinoma (NPC) before and after radiotherapy. [Method] 42 NPC patients were treated with radiotherapy as radiotherapy group and 40 healthy subjects as normal control group. The contents of VEGF and bFGF in peripheral blood of patients with NPC before and after radiotherapy were detected by enzyme-linked immunosorbent assay (ELISA) and compared with the control group. [Results] The serum levels of VEGF and bFGF in NPC patients before radiotherapy were significantly higher than those in control group (P <0.01). The levels of VEGF and bFGF in NPC patients decreased significantly at 3 months after radiotherapy, which was close to the control group (P> 0.05). Serum levels of VEGF and bFGF continued to be abnormal at 1 year after radiotherapy (P <0.01) The level returned to normal (P> 0.05). There was a positive correlation between serum VEGF and bFGF concentration before and after radiotherapy (P = 0.0011, r = 0.7981). [Conclusion] The serum levels of VEGF and bFGF in NPC patients are high, and the changes of VEGF and bFGF in serum of NPC patients have important clinical significance in the observation of clinical efficacy and prognosis.