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目的:探讨粪菌移植(FMT)联合聚乙二醇治疗顽固性功能性便秘的临床疗效及对患者生活质量及心理状态的影响。方法:选择第四军医大学西京消化病院2013年11月至2015年5月门诊顽固性功能性便秘患者35例,所有患者均行FMT治疗,同时联合聚乙二醇电解质散剂,疗程4周,采用便秘患者症状评分量表(KESS)、生存质量量表(PAC-QOL)、Zung焦虑自评量表(SAS)及抑郁自评量表(SDS)观察治疗前后及随访3个月便秘患者症状、生活质量及心理状态的改变。结果:治疗后及随访3个月时,患者的临床治愈率分别为37.1%、34.3%,改善率分别为77.1%、71.4%,KESS、PAC-QOL、SAS、SDS总评分均较治疗前明显减低(P<0.05)。治疗及随访期间均未发生严重不良反应。结论:FMT联合聚乙二醇能安全、有效的改善顽固性功能性便秘患者的相关症状,提高生活质量,改善异常心理状态,值得临床推广。
Objective: To investigate the clinical efficacy of fecal bacteria transplantation (FMT) combined with polyethylene glycol in the treatment of refractory functional constipation and its impact on the quality of life and psychological status of patients. Methods: Thirty-five patients with intractable functional constipation from November 2013 to May 2015 were selected from the Fourth Military Medical University Xijing Hospital of Peking Union Medical College. All patients underwent FMT and combined with polyethylene glycol electrolyte powder for 4 weeks. Constipation patients’ symptom scores, KESS, PAC-QOL, SAS, and SDS were observed before and after treatment and 3 months follow-up. Quality of life and psychological changes. Results: After treatment and at 3 months of follow-up, the clinical cure rates were 37.1% and 34.3%, respectively, and the improvement rates were 77.1% and 71.4% respectively. The total scores of KESS, PAC-QOL, SAS and SDS were significantly higher than those before treatment Decrease (P <0.05). No serious adverse reactions occurred during treatment and follow-up. Conclusion: FMT combined with polyethylene glycol can improve the related symptoms of patients with refractory functional constipation effectively, improve the quality of life and improve the abnormal psychological status, which is worthy of clinical promotion.