已经证实Ca~(2+)是生物体中一种重要介质,能改变细胞Ca~(2+)水平的药物,可望产生不同的药理作用,Ca~(2+)拮抗剂广泛用于冠心病和高血压的临床用药,因此Ca~(2+)拮抗剂的研究是筛选和开发心血管药物必不可少的手段。本文报道了从134种中国生药热水提取液中筛选对K~+挛缩具有抑制活性的药物, It has been proved that Ca~(2+) is an important mediator in the organism, and the drug that can alter the level of Ca~(2+) is expected to produce different pharmacological effects. Ca~(2+) antagonists are widely used in crowns. Heart disease and high blood pressure are clinically used. Therefore, the study of Ca 2+ antagonists is an indispensable means of screening and developing cardiovascular drugs. This article reports on the screening of drugs that have inhibitory activity against K~+ contraction from 134 Chinese crude drug hot water extracts.