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目的:探讨宫腹腔镜手术联合中西医药物(丹参注射液灌注与中药灌肠)治疗输卵管阻塞性不孕症对患者血清相关因子(IL-6、TNF-α、IFN-γ)的影响。方法:选择我院就诊的300例输卵管阻塞性不孕症患者,将其随机分为采用宫腹腔镜手术联合丹参注射液灌注与中药灌肠治疗的A组(100例)、宫腹腔镜手术联合丹参注射液灌注治疗的B组(100例)、宫腹腔镜手术联合中药灌肠的C组(100例),比较3组患者治疗前后血清IL-6、TNF-α、IFN-γ水平。结果:治疗后3组血清IL-6、TNF-α、IFN-γ水平较治疗前均显著性的降低(P<0.05);治疗后A组较B组、C组血清IL-6、TNF-α、IFN-γ水平显著性的降低(P<0.05);治疗后B组和C组血清IL-6、TNF-α、IFN-γ水平无显著性的差异(P>0.05)。结论:宫腹腔镜手术联合中西医药物较宫腹腔镜手术联合丹参注射液灌注或宫腹腔镜手术联合中药灌肠治疗输卵管阻塞性不孕症能更有效的降低血清IL-6、TNF-α、IFN-γ水平,值得临床推广应用。
Objective: To investigate the effect of hysteroscopic laparoscopic surgery combined with Chinese and Western medicine (Salviae Miltiorrhizae injection and Chinese medicine enema) on the serum level of IL-6, TNF-α and IFN-γ in patients with tubal obstruction infertility. Methods: Three hundred patients with obstructive tubal infertility who were treated in our hospital were randomly divided into group A (100 cases) treated with laparoscopic hysteroscopy combined with Salvia miltiorrhiza injection and Chinese medicine enema, laparoscopy combined with radix salviae miltiorrhizae The patients in group B (100 cases) and laparoscopic group (100 cases) in group C were enrolled in this study. The levels of IL-6, TNF-α and IFN-γ in the three groups were compared before and after treatment. Results After treatment, the levels of IL-6, TNF-α and IFN-γ in serum in three groups were significantly lower than those before treatment (P <0.05) (P <0.05). The levels of IL-6, TNF-α and IFN-γ in serum of group B and group C after treatment were not significantly different (P> 0.05). Conclusion: Hysteroscopic laparoscopic combined with traditional Chinese and western medicine laparoscopic surgery combined with Salvia miltiorrhiza injection or laparoscopic hysterectomy combined with traditional Chinese medicine enema in the treatment of tubal obstruction infertility can effectively reduce serum levels of IL-6, TNF-α, IFN -γ level, it is worth clinical application.