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目的 探讨以锝99—甲氧基异丁基腈 (99mTc MIBI)为显像剂的单光子发射型计算机断层扫描(SPECT) ,在颅内肿瘤立体定向放射外科治疗后疗效评价中的作用。方法 观察 1 8例颅内肿瘤患者行X 刀或γ 刀治疗后的CT、MRI及SPECT影像改变 ,结合病理结果分析SPECT显像与肿瘤放射外科治疗后疗效的关系。结果 SPECT所显示病灶区的 99mTc MIBI浓聚程度与肿瘤增殖活力密切相关 ,浓聚越明显 ,肿瘤活力越高 ,即复发的可能性越大 ,而放射性坏死灶仅见很淡或几乎没有 99mTc MIBI浓聚。结论 99mTc MIBI可反映脑肿瘤活力 ,以 99mTc MIBI为显像剂SPECT扫描可帮助区分颅内肿瘤立体定向放射外科治疗后的放射性坏死或复发。
Objective To investigate the effect of single photon emission computed tomography (SPECT) using technetium 99-methoxyisobutyronitrile (99mTc MIBI) as imaging agent in evaluating the curative effect of stereotactic radiosurgery for intracranial tumors. Methods The CT, MRI and SPECT images of 18 patients with intracranial tumors undergoing X knife or γ knife treatment were observed. The relationship between SPECT imaging and the therapeutic effect of radiosurgery was analyzed. Results The concentration of 99mTc MIBI in the lesion revealed by SPECT was closely related to the proliferation activity of the tumor. The more the concentration was, the higher the tumor activity was, the more likely it was to relapse. However, the radioactive necrosis showed only very little or no 99mTc MIBI concentration Poly. Conclusions 99mTc MIBI can reflect the brain tumor activity, 99mTc MIBI SPECT scan can help distinguish between intracranial tumor stereotactic radiosurgery after radiosurgery or recurrence.