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我们采用反转录-聚合酶键反应（RT-PCR）方法，观察了δ阿片受体肽类激动剂[D-Pen2.5]enkephalin（PDPE）及非肽类激动利BW373U86对δ受体mRNA表达的影响，并比较了两者作用的差异性。结果如下：（1）DPDPE作用24及48h可使δ受体mRNA表达水平显著降低，而BW373U86只在24h有显著抑制作用;（2）DPDPE在10－6mol／L时即可使δ受体的mRNA表达水平显著降低;而BW73U86在10－5mol／L时才有效。可见长时间（24h）给予肽类及非肽类δ阿片激动剂均可显著抑制δ受体的mRNA表达；DPDPE作用较强，作用时程较长。
We used reverse transcription-polymerase chain reaction (RT-PCR) method to observe the δ opioid receptor peptide agonist [D-Pen2.5] enkephalin (PDPE) and non-peptide agonist BW373U86 δ receptor mRNA The impact of the expression, and compared the difference between the two roles. The results were as follows: (1) DPDPE significantly reduced the expression of δ receptor mRNA at 24 h and 48 h, while BW373U86 had a significant inhibitory effect only at 24 h. (2) When DPDPE was 10-6 mol / L, mRNA expression was significantly reduced; while BW73U86 at 10-5mol / L was only effective. Visible for a long time (24h) given peptide and non-peptide δ opioid agonist can significantly inhibit δ receptor mRNA expression; DPDPE strong role in the longer course of action.