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目的探讨狼疮性肾炎患者医院感染临床与病理特征,以提高临床诊治水平。方法选取2010年4月-2013年4月135例狼疮性肾炎患者为研究对象,对其中发生医院感染的病例从感染部位、临床分型、临床病理特点和相关影响因素进行分析,数据采用SPSS16.0软件进行处理。结果 135例狼疮性肾炎患者医院感染57例,感染率42.22%;其中下呼吸道感染24例占42.1%;感染类型以急进型肾炎综合征、急性肾炎综合征感染率最高,分别为81.82%、61.54%;Ⅲ型感染率最高,为72.73%;其中易感因素有24h尿蛋白≥3.5g、血清白蛋白<30g/L、血肌酐升高、小管间质病变≥20%、激素应用时间长≥6个月、住院时间长≥60d、激素+环磷酰胺冲击治疗。结论狼疮性肾炎患者医院感染发生率较高,感染和狼疮临床活动、病理和治疗等各个方面均有相关性。
Objective To investigate the clinical and pathological features of nosocomial infection in patients with lupus nephritis so as to improve the clinical diagnosis and treatment. Methods From April 2010 to April 2013, 135 cases of lupus nephritis were selected as study subjects. The cases of nosocomial infection were analyzed from the site of infection, clinical classification, clinicopathological features and related factors. The data were analyzed by SPSS16. 0 software for processing. Results 135 cases of lupus nephritis hospital infection 57 cases, the infection rate was 42.22%; of which 24 cases of lower respiratory tract infection accounted for 42.1%; type of infection with acute nephritis syndrome, acute nephritis syndrome infection rates were 81.82%, 61.54 %; The highest infection rate of type Ⅲ was 72.73%; the predisposing factors were 24h urinary protein≥3.5g, serum albumin <30g / L, elevated serum creatinine, tubulointerstitial lesion≥20%, prolonged hormone application≥ 6 months, hospital stay longer than 60d, hormone + cyclophosphamide impact treatment. Conclusion The incidence of nosocomial infections in patients with lupus nephritis is high, and the infection is related to the clinical activity, pathology and treatment of lupus.