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目的探讨硫酸镁对电离辐射诱发的脑组织损伤的脑保护作用。方法将成熟的SD大鼠60只随机分为空白对照组、实验对照组和硫酸镁实验用药组,用6MeV电子线对实验大鼠进行20Gy全脑单次垂直照射,分别于1、7、14和30d处死、取样,应用等离子直读光谱仪定量分析大鼠脑组织中钙、镁离子含量,用干湿重法测定脑组织含水量,并与空白对照组进行比较。同时对各组大鼠脑组织进行了病理观察。结果与空白对照组相比,实验对照组大鼠脑水肿明显,脑组织中钙离子含量显著升高(P<0.05),镁离子含量显著下降(P<0.05);与实验对照组相比,硫酸镁实验用药组大鼠脑组织Ca2+变化不大,脑水肿程度较前者轻(P<0.05)。结论早期使用硫酸镁可抑制辐射引起的脑组织中钙离子的超载,减轻脑组织水肿和损伤的程度。
Objective To investigate the protective effects of magnesium sulfate on the damage of brain tissue induced by ionizing radiation. Methods Sixty adult Sprague-Dawley rats were randomly divided into blank control group, experimental control group and magnesium sulfate experimental group. The rats were subjected to 20Gy single vertical irradiation with 6MeV electron beam, And sacrificed on the 30th day. The contents of calcium and magnesium in rat brain were quantitatively analyzed by plasma direct reading spectrometer. The water content of brain tissue was determined by dry-wet method and compared with that of blank control group. At the same time, the brain tissue of each group was observed. Results Compared with the blank control group, the brain edema in the experimental control group was significantly increased, the content of calcium in the brain tissue increased significantly (P <0.05) and the content of magnesium ion decreased significantly (P <0.05). Compared with the experimental control group, Magnesium sulfate experimental group rats brain Ca2 + little change, the degree of brain edema lighter than the former (P <0.05). Conclusion Early use of magnesium sulfate can inhibit radiation-induced overload of calcium in brain tissue and reduce the extent of brain edema and injury.