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华蟾素是从中药干蟾皮中提取出来的水溶性制剂,属于国家二类新药。已有大量的研究证实,华蟾素可以用于防治肝癌、肺癌、乳腺癌等多种恶性肿瘤,可通过抑制肿瘤细胞增殖、诱导凋亡、增强免疫机能、抑制肿瘤血管生成等方面发挥抗肿瘤作用。文章主要总结华蟾素抗恶性肿瘤的不同机制及其不良反应等方面的研究进展。
Cinobufagin is a water-soluble preparation extracted from dried toad skin of traditional Chinese medicine and belongs to the second category of new drugs in the country. A large number of studies have confirmed that cinobufacini can be used to prevent and treat many kinds of malignant tumors such as liver cancer, lung cancer and breast cancer and exert antitumor activity by inhibiting tumor cell proliferation, inducing apoptosis, enhancing immune function and inhibiting tumor angiogenesis effect. The article summarizes the different mechanisms of cinobufacini anti-cancer and its adverse reactions and other aspects of research.