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目的探讨子宫性索样肿瘤(uterine sex cord-like tumors,USCLTs)的临床病理特征、诊断与鉴别诊断、治疗及预后。方法复习3例USCLTs的临床病理资料,并结合文献进行讨论。结果 3例均为成年女性,肿瘤组织呈巢状、梁索状排列,也可呈小腺泡状或微小乳头状结构,其中1例呈浸润性生长,肿瘤细胞轻度异型性,核分裂罕见。免疫表型:通常瘤细胞表达2种性索肿瘤标志物,也可表达上皮、平滑肌或间叶组织标志物。结论 USCLTs是一种罕见的、含性索结构的多表型肿瘤,具有不确定恶性潜能,术后应密切随访观察。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis, treatment and prognosis of uterine sex cord-like tumors (USCLTs). Methods The clinical and pathological data of 3 cases of USCLTs were reviewed and discussed in combination with the literature. Results All three cases were adult female. The neoplasm of the tumor was nested, arranged in the form of beam cords, and also showed small acinar or tiny papillary structures. One of them was infiltrative growth, mild atypical tumor cells and rare mitosis. Immunophenotypes: Normally, tumor cells express two sex tumors markers and can also express epithelial, smooth muscle, or mesenchymal markers. Conclusions USCLTs is a rare, multi-phenotype tumor with a cord-shaped structure. It has uncertain malignant potential and should be followed up closely.