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目的探讨利多卡因对慢性阻塞性肺疾病急性加重期(AECOPD)患者的治疗效果。方法选择在我院治疗的慢性阻塞性肺疾病急性加重期患者166例,将其分为试验组92例与对照组74例。对照组予以常规治疗,试验组在常规治疗的基础上雾化吸入利多卡因,观察两组患者的临床治疗效果。结果两组患者治疗后基本生命体征和动脉血气较治疗前均有所改善,试验组患者雾化吸入利多卡因1h后,PaO2和氧合指数较同时期对照组升高更快,差异有统计学意义(P<0.05);两组患者治疗后第4天,咳嗽、咳痰和喘息症状均有所缓解,试验组患者咳嗽和喘息症状缓解率高于对照组,差异有统计学意义(P<0.05)。结论在治疗AECOPD中,雾化吸入利多卡因可早期改善氧合,缓解患者咳嗽和喘息症状具有良好的效果。
Objective To investigate the therapeutic effect of lidocaine on patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods A total of 166 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) treated in our hospital were divided into two groups, 92 cases in trial group and 74 cases in control group. The control group was given routine treatment. The experimental group was given inhaled lidocaine atomically on the basis of routine treatment, and the clinical effect of the two groups was observed. Results After treatment, the basic vital signs and arterial blood gases were improved in both groups. After the inhalation of lidocaine for 1 h in the test group, the PaO2 and oxygenation index increased more rapidly than the control group in the same period (P <0.05). On the fourth day after treatment, the symptoms of cough, expectoration and wheezing were relieved in both groups. The relief rate of cough and wheezing in the test group was higher than that in the control group (P <0.05). Conclusion In the treatment of AECOPD, inhaled lidocaine can improve oxygenation early and relieve the symptoms of cough and wheeze.