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目的:通过检测急性缺血性脑卒中患者血浆S100β蛋白、NSE水平,探讨其动态变化,为临床诊断、治疗提供依据。方法:选择急性缺血性脑卒中患者(151例)为研究对象,未卒中患者(100例)作对照,血浆S100β蛋白检测采用ELISA法;NSE采用电化学发光法。行头颅核磁共振检查计算脑梗死体积大小,按美国国立卫生研究所中风量表(NIHSS评分)进行神经功能缺损程度评估。结果:(1)S-100β蛋白与HDL-C负相关(P<0.05),与TC、LDL-C正相关(P<0.05)。(2)急性缺血性脑卒中组血浆S100β蛋白、NSE水平1 d～7 d明显高于对照组(P<0.05),14天恢复正常水平。(3)血浆S100β蛋白、NSE水平随脑梗死体积增加而呈递增趋势(P<0.05)(4)血浆S100β、NSE水平随神经功能缺损程度增加而呈递增趋势(P<0.05)。结论:急性缺血性脑卒中患者S100β、NSE蛋白水平明显升高,其与脑梗死体积相关,与神经功能缺损程度相关。
Objective: To detect plasma S100βprotein and NSE levels in patients with acute ischemic stroke and to explore its dynamic changes, and to provide evidence for clinical diagnosis and treatment. Methods: One hundred and fifteen patients with acute ischemic stroke were enrolled in this study. 100 patients without stroke were selected as controls. Serum S100β protein was detected by ELISA and NSE by electrochemiluminescence. The size of cerebral infarction was calculated by cranial magnetic resonance imaging (MRI). The degree of neurological deficit was evaluated according to the National Institutes of Health Stroke Scale (NIHSS score). Results: (1) S-100β protein was negatively correlated with HDL-C (P <0.05) and positively correlated with TC and LDL-C (P <0.05). (2) The levels of S100βprotein and NSE in acute ischemic stroke group were significantly higher than those in control group (P <0.05) on day 1 to 7, and returned to their normal levels on day 14. (3) Plasma S100βprotein and NSE levels increased with the increase of cerebral infarction volume (P <0.05). (4) Plasma S100β and NSE levels showed an increasing trend with the increase of neurological deficit (P <0.05). Conclusion: The levels of S100β and NSE in patients with acute ischemic stroke are significantly increased, which are correlated with the volume of cerebral infarction and with the degree of neurological deficits.