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新生儿血小板减少症是免疫性血小板减少性紫癜(ITP)的一种有潜在生命危险的并发症.因为人胎盘有IgG的Fc受体,故母体的IgG抗血小板抗体可进入胎儿循环.有活动性ITP的孕妇或有ITP史而分娩时病情缓解,血小板数正常的孕妇都可能有循环抗血小板抗体,导致新生儿血小板减少,因此这些病人的处理是一临床难题.作者对23例曾患过或正患有不明原因的血小板减少,同时骨髓吸片中有多量巨核细胞的孕妇作了研究,其中12例为活动性ITP,11例有ITP史而分娩时临床缓解.病人均无系统性疾病,脾肿大或血
Neonatal thrombocytopenia is a potentially life-threatening complication of immune thrombocytopenic purpura (ITP), because maternal IgG anti-platelet antibodies can enter the fetal circulation because of the IgG Fc receptor. Sexual ITP pregnant women or pregnant with ITP history and childbirth ease, normal number of pregnant women may have circulating anti-platelet antibodies, resulting in neonatal thrombocytopenia, so the treatment of these patients is a clinical problem.The author of 23 patients had Or are suffering from unexplained thrombocytopenia, while the number of pregnant women with large numbers of megakaryocytes in bone marrow aspirates were studied, of which 12 cases of active ITP, 11 cases of ITP history and clinical remission at delivery .No patients with systemic disease Splenomegaly or blood