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甲状腺转录因子-1(TTF-1)是一种调节甲状腺和肺特异基因表达的蛋白,也是甲状腺特异基因的一个激活因子,属于同区域转录因子自然杀伤X2(NX2)家族,表达于胚胎期和发育成熟的甲状腺和肺上皮细胞中,部分脑组织中也有表达。同时,它作为一种对肺及甲状腺来源的肿瘤选择性非常高的标记物,在肿瘤诊断和鉴别诊断中正被越来越广泛地应用,且有人将其作为肺癌的一项预后指标。本文就TTF-1在肺癌诊断和鉴别诊断中的应用及其与肺癌预后关系的研究现状作一综述。
Thyroid transcription factor-1 (TTF-1) is a protein that regulates thyroid and lung specific gene expression and is also an activator of thyroid-specific genes belonging to the same region of the transcription factor natural killer X2 (NX2) family, expressed in embryonic and Mature thyroid and lung epithelial cells, some of the brain tissue also expressed. At the same time, it is used as a marker of lung and thyroid-derived tumors with high selectivity. It is being used more and more widely in the diagnosis and differential diagnosis of tumors. Some people use it as a prognostic indicator of lung cancer. This review summarizes the application of TTF-1 in the diagnosis and differential diagnosis of lung cancer and its relationship with the prognosis of lung cancer.