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报道52例高血压病人服降压药双氢克尿噻、心得安、复方降压片和硝苯啶1～2月后血脂的变化,结果显示,双克(25～50mg/日)对血脂的主要影响是升高TG,加用心得安(30mg/日)后,TG升高幅度更大;TC有上升趋势,HDL-C变化较小。复降片(3片/日)对血脂的影响较大。不仅TG明显升高、TC也有明显升高,而HDL-C则有显著下降、HDL-C/TC比值下降也十分显著。硝苯啶(30mg/日)对血脂也产生不利影响,血TG浓度上升,TC浓度增加,而HDL-C变化不大。这种变化已被看作为对长期接受这些药物治疗的病人外加了一个致动脉粥样硬化的危险因素。
Reported 52 cases of hypertensive patients taking antihypertensive drugs hydrochlorothiazide, propranolol, compound antihypertensive tablets and nifedipine 1-2 months after the change of blood lipids, the results showed that two grams (25 ~ 50mg / day) on lipid The main effect is to increase TG, plus propranolol (30mg / day), TG increased more; TC has an upward trend, small changes in HDL-C. Complex decline tablets (3 / day) greater impact on blood lipids. Not only the TG was significantly increased, TC was also significantly increased, while HDL-C was significantly decreased, HDL-C / TC ratio is also very significant decline. Nifedipine (30mg / day) also has an adverse effect on blood lipids, blood TG levels increased, TC concentration increased, while HDL-C little change. This change has been seen as a risk factor for atherosclerosis in patients receiving long-term treatment with these drugs.