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目的探讨皮肌炎合并乳腺恶性肿瘤的临床特征、诊治及预后情况。方法回顾性分析我科自2008年以来收治的3例皮肌炎合并乳腺恶性肿瘤患者的临床资料,就两者关系结合文献进行分析。结果3例皮肌炎合并乳腺恶性肿瘤患者中2例行乳腺癌改良根治术,病理报告为浸润性导管癌(淋巴结14/21枚转移)和原位癌(淋巴结0/17枚转移,伴4枚癌结节),因术后不能耐受静脉化疗,予内分泌治疗。1例行乳房肿瘤切除术及腋窝淋巴结活检术,2个月后因肺间质病死亡。结论女性皮肌炎患者易伴发乳腺恶性肿瘤且预后差,对明确诊断为皮肌炎的女性患者有必要进行乳腺恶性肿瘤的筛选。
Objective To investigate the clinical features, diagnosis, treatment and prognosis of dermatomyositis combined with breast cancer. Methods The clinical data of 3 patients with dermatomyositis with malignant breast neoplasm treated in our department since 2008 were retrospectively analyzed, and the relationship between them was analyzed in combination with the literature. Results Of the 3 cases with dermatomyositis and breast cancer, 2 cases underwent modified radical mastectomy. The pathological reports were invasive ductal carcinoma (14/21 lymph nodes metastases) and carcinoma in situ (0/17 lymph node metastases with 4 Metastatic nodules), because of postoperative can not tolerate intravenous chemotherapy, to endocrine therapy. A routine breast tumor resection and axillary lymph node biopsy, 2 months after the death of pulmonary interstitial disease. Conclusions Female patients with dermatomyositis tend to have breast cancer and the prognosis is poor. It is necessary to screen breast cancer for female patients with definite diagnosis of dermatomyositis.