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A series of 2,6-disubstituted-4-morpholinothieno[3,2-d]pyrimidine derivatives were synthesized and their cytotoxic activity against H460,HT-29,MDA-MB-231,U87MG and H1975 cancer cell lines were evaluated in vitro.Most of the target compounds exhibited moderate to excellent activity to the tested cell lines.The most promising compound 23(0.84μmol/L,0.23μmol/L, 2.52μmol/L,1.80μmol/L) was 1.0,2.9,29.3 and 4.3 times more active than GDC-0941(0.87μmol/L,0.66μmol/L,73.8μmol/L, 7.77μmol/L) against H460,HT-29,MDA-MB-231 and U87MG cell lines,respectively.
A series of 2,6-disubstituted-4-morpholinothieno [3,2-d] pyrimidine derivatives were synthesized and their cytotoxic activity against H460, HT-29, MDA-MB-231, U87MG and H1975 cancer cell lines were evaluated in vitro .Most of the target compounds exhibited a moderate to excellent activity to the tested cell lines. The most promising compound 23 (0.84 μmol / L, 0.23 μmol / L, 2.52 μmol / L, 1.80 μmol / L) was 1.0, 2.9, 29.3 and 4.3 times more active than GDC-0941 (0.87 μmol / L, 0.66 μmol / L, 73.8 μmol / L, 7.77 μmol / L) against H460, HT-29, MDA-MB-231 and U87MG cell lines, respectively.