论文部分内容阅读
用大孔树脂(AB8)柱层析、硅胶柱层析、SephadexLH20柱层析、及制备性HPLC等方法,从大蒜(AliumsativumL.)水溶性部分分到6个化合物,并鉴定其结构,它们分别是protoisoerubosideB(I),erubosideB(I),isoerubosideB(II),sativosideC(IV),腺苷(V)和色氨酸(VI)。其中I和II为两个新的甾体皂甙类化合物。并测试了它们对血液系统的作用,发现大蒜总甙有抗血小板聚集和提高纤溶活性,isoerubosideB有明显的延长血液凝固时间和提高纤溶活性,protoisoerubosideB有显著的提高纤溶活性,腺苷则有抗血小板聚集活性和提高纤溶活性,sativosideC由于量少未测活性。其余化合物均无活性。
The water-soluble fractions of garlic (Aliumsativum L.) were divided into 6 compounds by means of macroporous resin (AB-8) column chromatography, silica gel column chromatography, SephadexLH-20 column chromatography, and preparative HPLC. The structures are proto-iso-eruboside-B (I), eruboside-B (I), iso-eruboside-B (II), sativoside-C (IV), adenosine (V) and tryptophan (VI). ). Among them, I and II are two new steroidal saponins. And tested their effect on the blood system, found that total garlic has anti-platelet aggregation and increased fibrinolytic activity, isoerubosideB has significant prolongation of blood clotting time and increased fibrinolytic activity, protoisoerubosideB Significantly increased fibrinolytic activity, adenosine has antiplatelet aggregation activity and increased fibrinolytic activity, sativoside C due to the small amount of untested activity. The rest of the compounds were inactive.