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目的 研究持续静滴安定治疗惊厥持续状态 (SC)的疗效 ,探讨其安全有效的安定静滴速度及有效血药浓度。方法 选择SC患儿 42例。其中 ,观察组 2 2例 ,予持续静滴安定治疗 ;对照组 2 0例 ,给予苯巴比妥负荷量肌肉注射治疗。将两组控制发作所需时间 (以分钟计 )进行比较 ,计算P值。同时观察观察组的有效安全静滴速度及有效安全血药浓度。结果 ①观察组发作控制时间较对照组明显为短 (t =3 2 2 ,P <0 0 5 )。②安定血药浓度的安全有效范围为 (5 37 6 3± 2 33 2 7)mg/L。 结论 持续静滴安定是治疗小儿SC的安全有效的方法。
Objective To study the efficacy of continuous intravenous diazepam in the treatment of convulsive persistence (SC) and to explore its safe and effective diazepam and effective plasma concentration. Methods Forty-two children with SC were selected. Among them, the observation group 22 cases, to continuous intravenous stability treatment; control group 20 patients, given phenobarbital load intramuscular injection therapy. The time required for both episodes to control seizures (in minutes) was compared to calculate the P value. At the same time observe the observation group effective and safe intravenous infusion rate and effective safe blood drug concentration. Results ① The onset time of the observation group was significantly shorter than that of the control group (t = 32 2, P <0 05). ② The safe and effective range of diastolic blood concentration was (5 37 6 3 ± 2 33 27) mg / L. Conclusion Continuous intravenous diazepam is a safe and effective method for the treatment of pediatric SC.