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睾丸切除 (ORX)大鼠骨质疏松动物模型是研究男性骨质疏松的重要工具。ORX对生长期及成熟期大鼠骨骼的影响不同 ,生长期大鼠ORX后骨量减少主要是由于峰值骨量的积累减弱 ,而成熟期大鼠ORX后则出现骨量的净丢失增加。另外考虑到年龄的影响 ,老龄雄鼠ORX后造成的骨量减少可能含盖了增龄和去势的双重作用。由于雄激素和雌激素对雄鼠骨骼的生长和骨量的维持均起着重要的作用 ,ORX术后造成雄鼠骨量减少或骨质疏松是雄激素缺乏引起 ,还是雌激素缺乏引发目前观点还不一致。尽管如此 ,药物干预防治ORX后骨质疏松的研究已广泛展开并初见成效
Orchidectomy (ORX) rat osteoporosis animal model is an important tool for the study of male osteoporosis. ORX had different effects on skeletal growth in mature and aged rats. The decrement of ORX in growing rats was mainly due to the weakened peak bone mass, while the net loss of bone mass in mature rats increased after ORX. In addition, taking into account the impact of age, bone loss caused by ORX in old male rats may cover the dual role of aging and castration. Because androgens and estrogens play an important role in the growth of skeletal bone and the maintenance of bone mass in male rats, osteopenia or osteoporosis caused by androgen deficiency in male rats after ORX, or the current lack of estrogen Not the same. In spite of this, the research on the prevention and treatment of osteoporosis after ORX by pharmaceutical intervention has been carried out widely and has achieved initial success