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目的:比较分析广西壮族与汉族患者肾移植术后不同时期他克莫司血药浓度的差别。方法:采用酶放大免疫分析(EMIT)法,对17例壮族和28例汉族患者肾移植术后的他克莫司血药浓度进行监测,按族别、术后时间分组,同时根据肾中毒和移植排斥反应的判断标准,对所测得的结果及疗效进行统计学分析。结果:肾移植术后<1、1~3、4~6、7~12、13~24、>24个月等时间段他克莫司平均血药浓度,壮族患者为(11.3±3.0)、(9.3±2.4)、(7.8±2.1)、(7.1±1.8)、(5.7±2.3)和(4.5±1.5)μg/L,汉族患者为(9.7±2.2)、(8.9±3.6)、(8.1±1.7)、(6.9±2.6)、(5.4±3.1)和(4.6±1.4)μg/L。除了在术后1个月内,壮族与汉族他克莫司平均血药浓度比较差异有统计学意义(P<0.05)外,其余时间段均差异无统计学意义(P>0.05)。不同时期壮族与汉族患者发生中毒反应时他克莫司平均血药浓度和血肌酐(Scr)值也差异无统计学意义(P>0.05)。结论:广西壮族患者他克莫司血药浓度可参考汉族的血药浓度范围。
OBJECTIVE: To compare and analyze the differences of tacrolimus blood concentration between different stages of kidney transplantation in Guangxi Zhuang and Han nationality patients. Methods: Enzyme immunoassay (EMIT) method was used to monitor the plasma concentrations of tacrolimus in 17 cases of Zhuang and 28 Han patients after kidney transplantation. The plasma concentrations of tacrolimus in different groups were analyzed by ethnicity and postoperative time. At the same time, Graft rejection criteria, the measured results and the efficacy of statistical analysis. Results: The average tacrolimus plasma concentrations in the patients with renal transplantation (1,1 1, 3,4-6, 7-12, 13-24, and 24 months) were (11.3 ± 3.0) (9.3 ± 2.4), (7.8 ± 2.1), (7.1 ± 1.8), (5.7 ± 2.3) and (4.5 ± 1.5) μg / L in Han nationality and (9.7 ± 2.2) and ± 1.7), (6.9 ± 2.6), (5.4 ± 3.1) and (4.6 ± 1.4) μg / L, respectively. Except within 1 month after operation, the average blood concentration of tacrolimus between Zhuang and Han was significantly different (P <0.05), but there was no significant difference in other time periods (P> 0.05). There was no significant difference in tacrolimus plasma concentration and serum creatinine (Scr) between Zhuang and Han patients in different periods (P> 0.05). Conclusion: The plasma concentration of tacrolimus in Guangxi Zhuang nationality patients can refer to the blood concentration range of Han nationality.