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目的探讨可溶性细胞间粘附分子 1(solubleintercellularadhesionmolecule 1,sICAM 1)在急、慢性肝炎的水平及临床意义。方法应用酶联免疫吸附实验检测 6 7例急、慢性肝炎患者血清sICAM 1水平 ,并同时检测肝功能。结果急、慢性肝炎患者血清sICAM 1水平明显高于正常人水平 (P <0 .0 1,P <0 .0 5 ) ,且随着肝细胞损伤程度的加重而升高。结论血清sICAM 1水平可反映肝炎患者的肝细胞坏死程度。
Objective To investigate the clinical significance and significance of sICAM 1 in patients with acute and chronic hepatitis induced by soluble intercellular adhesion molecule 1 (sICAM 1). Methods Serum levels of sICAM 1 in 67 patients with acute and chronic hepatitis were detected by enzyme-linked immunosorbent assay (ELISA), and liver function was detected at the same time. Results Serum levels of sICAM 1 in patients with acute and chronic hepatitis were significantly higher than those in normal controls (P <0.01, P <0.05), and increased with the severity of hepatocellular injury. Conclusion Serum sICAM 1 levels can reflect the degree of hepatocellular necrosis in patients with hepatitis.