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氨甲蝶呤是一种叶酸拮抗剂,临床上用作抗代谢剂和抗炎剂。本文报道应用氨甲蝶呤对顽固性炎症性肠道疾病的治疗结果。病人和方法 21例顽固性炎症性肠道疾病患者,包括节段性肠炎14例,慢性溃疡性结肠炎7例。其中17例同时服用不同剂量的皮质激素,14例服用柳氮磺胺吡啶或灭滴灵。21例中10例曾用硫唑嘌呤或6-巯基嘌呤无效。治疗方法:患者继续服用柳氮磺胺吡啶或灭滴灵。视临床效果而将强的松逐渐减量。氨甲蝶呤每周肌注1次,每次25mg,连续12周。若临床症状和客观指标有所改善,则改为口服,并逐渐减量。
Methotrexate is a folic acid antagonist that is clinically used as an antimetabolite and anti-inflammatory agent. This article reports the results of methotrexate treatment of refractory inflammatory bowel disease. Patients and Methods Twenty-one patients with refractory inflammatory bowel disease, including 14 cases of Crohn’s disease and 7 cases of chronic ulcerative colitis. Seventeen of them took different doses of corticosteroids at the same time, and 14 took sulfasalazine or metronidazole. Of the 21 patients, 10 had been inactive with azathioprine or 6-mercaptopurine. Treatment: Patients continue to take sulfasalazine or metronidazole. Depending on the clinical effect of prednisone tapering. Methotrexate intramuscular injection once a week, each 25mg, for 12 weeks. If the clinical symptoms and objective indicators have improved, then changed to oral, and gradually reduced.