分子遗传学研究表明早老蛋白基因 (PS)突变是家族性阿尔茨海默疾病家系中最常见的遗传性基因突变。因此 PS功能的研究成为近年来阿尔茨海默疾病研究领域的热点。本文综述了 PS参与调节 Notch信号通路和Wnt信号通路信号传导的研究进展 ,以及 PS与神经细胞程序性死亡的关系 ,详细讨论了 PS即 γ分泌酶这一假说 ,并概述了 PS的其它相互作用蛋白及其相互作用的生物学意义 Molecular genetic studies have shown that premature senile protein gene (PS) mutations are the most common inherited genetic mutations in familial Alzheimer’s disease pedigrees. Therefore, the study of PS function has become a hot area in the field of Alzheimer’s disease in recent years. This review summarizes the progress of PS involved in the regulation of signal transduction of Notch and Wnt signaling pathways and the relationship between PS and neuronal apoptosis. The hypothesis that PS is a γ secretase is discussed in detail, and other interactions of PS The biological significance of proteins and their interactions