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脑梗死(cerebral infarction,CI)是常见的脑血管疾病,严重影响人类的健康;动脉粥样硬化(atherosclerosis,AS)是脑梗死发生的一个重要因素,颈动脉粥样硬化斑块尤其是易损斑块的形成,是缺血性心脑血管病的共同基础;基质金属蛋白酶-2(MMP-2)可以对动脉粥样硬化斑块的纤维帽与基底膜产生裂解作用及参与血管内膜的炎性反应,其在血液中的病理性增高可影响动脉粥样硬化斑块的稳定性,是导致斑块破裂、引起脑梗死的关键因素之一,并对脑梗死的程度、预后有重要影响。
Cerebral infarction (CI) is a common cerebrovascular disease that seriously affects human health. Atherosclerosis (AS) is an important factor in the development of cerebral infarction. Carotid atherosclerotic plaque is especially vulnerable Plaque formation is the common basis of ischemic cardiovascular and cerebrovascular diseases. Matrix metalloproteinase-2 (MMP-2) may play a role in the cleavage of the fibrous cap and basement membrane of atherosclerotic plaques and in the endothelium Inflammatory reaction, the pathological increase in the blood can affect the stability of atherosclerotic plaque, which is one of the key factors leading to plaque rupture and causing cerebral infarction, and has an important influence on the degree and prognosis of cerebral infarction .