【摘 要】
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Background The hemostatic system is complex and evolves continuously since gestation and well into the adult years,in a process known as “developmental hemostasis.”Data sources A comprehensive review was performed after an extensive literature search on P
【机 构】
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Neonatology Department (Reference Center for Congenital Heart Diseases),S(a)o Jo(a)o University Hosp
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Background The hemostatic system is complex and evolves continuously since gestation and well into the adult years,in a process known as “developmental hemostasis.”Data sources A comprehensive review was performed after an extensive literature search on PubMed/MEDLINE concerning developmental hemostasis during the neonatal period.Relevant cross references were also included.Results Although part of a system,each component of the hemostatic system evolves differently,with many displaying both quantitative and qualitative age-related differences.This leads to drastic disparities between the coagulation system of neonates and both other children\'s and adults\',while still maintaining a generally balanced and physiological hemostasis.The motives behind this process remain to be fully elucidated but may be,at least in part,related to non-hemostatic factors.Conclusions Knowledge regarding “developmental hemostasis” is essential for everyone caring for newborns or even chil-dren in general and in this review,we describe each hemostatic system component\'s neonatal characteristics and age-related progression as well as explore some of the possible physiological motives behind the process.
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