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目的:建立麻辛止咳胶囊质量标准。方法:用薄层色谱法对处方中的辛夷、枳壳、黄芩、细辛进行定性鉴别;用高效液相色谱法对样品中的麻黄碱进行含量测定。结果:薄层鉴别的色谱斑点清晰,阴性对照无干扰;含量测定盐酸麻黄碱进样量在0.249～7.470μg呈良好的线性关系,平均回收率为97.50%(n=5),RSD为0.86%。结论:定性、定量方法简便、专属、准确,可用于麻辛止咳胶囊的初步质量控制。
Objective: To establish the quality standard of Maxing Zhike Capsule. Methods: The prescription of Xinyi, Fructus Aurantii, Radix Scutellariae and Asarum were qualitatively identified by TLC. The contents of ephedrine in the samples were determined by high performance liquid chromatography. Results: The chromatographic spots identified by TLC were clear and the negative control had no interference. The content of ephedrine hydrochloride showed good linearity in the range of 0.249-7.470μg with the average recovery of 97.50% (n = 5) and RSD of 0.86% . Conclusion: The qualitative and quantitative methods are simple, accurate and accurate and can be used for preliminary quality control of Maxing Zhike Capsule.